Omega-3 deficiency and neurodegeneration in the substantia nigra: Involvement of increased nitric oxide production and reduced BDNF expression
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- 作者：Henriqueta Dias Cardosoa ; 1 ; Eraldo Fonseca dos Santos Juniora ; 1 ; David Filipe de Santanaa ; Catarina Gonç ; alves-Pimentela ; Monara Kaé ; lle Angelima ; Alinny R. Isaaca ; Clá ; udia Jacques Lagranhab ; Rubem Carlos Araú ; jo Guedesc ; Eduardo Isidoro Beltrã ; od ; Edgar Moryae ; Marcelo Cairrã ; o Araú ; jo Rodriguesa ; Belmira Lara da Silveira Andrade-da-Costaa ; bl@ufpe.br" class="auth_mail ; belmira@gmail.com" class="auth_mail
- 关键词：Brain-derived neurotrophic factor ; Lipoperoxidation ; Docosahexaenoic acid ; Dopamine ; Oxidative stress ; Striatum
- 刊名：Biochimica et Biophysica Acta (BBA)/General Subjects
- 出版年：June 2014
- 年：2014
- 卷：1840
- 期：6
- 页码：1902-1912
- 全文大小：1755 K
文摘
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DHA deficiency increases nitric oxide levels in the corpus striatum.
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DHA deficiency reduces BDNF-expressing neurons in the substantia nigra.
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DHA deficiency over two generations impairs striatum antioxidant resources.