刊名:The Journal of Steroid Biochemistry and Molecular Biology
出版年:2017
出版时间:March 2017
年:2017
卷:167
期:Complete
页码:153-161
全文大小:677 K
卷排序:167
文摘
Estrogens maintain meiotic arrest of fish oocytes. Estrogens act through GPER/EGFR pathway to maintain meiotic arrest. PGRMC1 is required for expression of EGFR on oocyte membrane and meiotic arrest. Bisphenol A prevents oocyte maturation through GPER/EGFR pathway. 2-hydroxy-estradiol-17β acts as a GPER antagonist to promote oocyte maturation.