Hakai, an E3-ligase for E-cadherin, stabilizes δ-catenin through Src kinase

详细信息    查看全文

• 作者：Hridaya Shrestha^a ; Taeyong Ryu^a ; Young-Woo Seo^b ; So-Yeon Park^c ; Yongfeng He^a ; Weiye Dai^a ; Eunsook Park^b ; Shishli Simkhada^a ; Hangun Kim^c ; Keesook Lee^d ; ^{klee@jnu.ac.kr} ; Kwonseop Kim^a ; ^{koskim@jnu.ac.kr}
• 关键词：δ-Catenin ; Hakai ; E-cadherin
• 刊名：Cellular Signalling
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：31
• 期：Complete
• 页码：135-145
• 全文大小：1852 K
• 卷排序：31

文摘

Hakai increases the stability of δ-catenin regardless of its E3 ligase activity. Hakai and δ-catenin do not associate physically. Hakai stabilizes δ-catenin through Src kinase. δ-Catenin mainly localizes in the plasma membrane regardless of E-cadherin endocytosis after Hakai overexpression.