Testosterone stimulates CYP24A1and inhibits CYP27B1 placental gene expression.
Testosterone phosphorylates CREB in a cAMP independent and AR dependent manner.
The placental VD-dependent expression of hCTD is reduced by androgen exposure.
Male placental cotyledons express less CYP27B1 and hCTD mRNA compared to females.
Male newborns had lower serum umbilical cord hCTD concentration compared to females.