Evidence of sexual dimorphism in placental vitamin D metabolism: Testosterone inhibits calcitriol-dependent cathelicidin expression
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- 作者：Andrea Olmos-Ortiza ; g ; Janice Garcí ; a-Quiroza ; Rebeca Ló ; pez-Marureb ; Irma Gonzá ; lez-Curielc ; Bruno Rivas-Santiagod ; Aleida Olivarese ; Euclides Avilaa ; David Barreraa ; Ali Halhalia ; Felipe Caldiñ ; of ; Fernando Larreaa ; Lorenza Dí ; aza ; lorenzadiaz@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：25OHD3 ; 25-hydroxyvitamin D3 ; AR ; Androgen Receptor ; cAMP ; cyclic AMP ; CRE ; cAMP response elements ; CREB ; cAMP response element binding protein ; DHT ; 5α-dihydrotestosterone ; E2 ; 17β-estradiol ; hCTD ; human Cathelicidin ; VD ; vitamin D ; VDR ; vitamin D receptor
- 刊名：Journal of Steroid Biochemistry and Molecular Biology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：163
- 期：Complete
- 页码：173-182
- 全文大小：1397 K
文摘
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Testosterone stimulates CYP24A1and inhibits CYP27B1 placental gene expression.
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Testosterone phosphorylates CREB in a cAMP independent and AR dependent manner.
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The placental VD-dependent expression of hCTD is reduced by androgen exposure.
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Male placental cotyledons express less CYP27B1 and hCTD mRNA compared to females.
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Male newborns had lower serum umbilical cord hCTD concentration compared to females.