刊名:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
出版年:2017
出版时间:March 2017
年:2017
卷:1864
期:3
页码:594-603
全文大小:1535 K
卷排序:1864
文摘
Cysteine protease cathepsin K (CatK) cleaves and inactivates the chemokine SDF-1α. CatK cleavage products of SDF-1α impair invasion of GSLCs in vitro. CXCR4 inhibitor plerixafor inhibits invasion of GSLCs in vitro. CatK and SDF-1α colocalize in glioma stem-like cell niches in glioblastoma tissue. CatK activity can prevent homing of GSLCs to their therapy-protective niches.