MAPT haplotype diversity in multiple system atrophy
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- 作者：Catherine Labbé ; a ; Michael G. Heckmanb ; Oswaldo Lorenzo-Betancora ; Melissa E. Murraya ; Kotaro Ogakia ; Alexandra I. Soto-Ortolazaa ; Ronald L. Waltona ; Shinsuke Fujiokaa ; Shunsuke Kogaa ; Ryan J. Uittic ; Jay A. van Gerpenc ; Ronald C. Petersend ; Neill R. Graff-Radfordc ; Steven G. Younkina ; Bradley F. Boeved ; William P. Cheshire Jr.c ; Phillip A. Lowd ; Paola Sandronid ; Elizabeth A. Coond ; Wolfgang Singerd ; Zbigniew K. Wszolekc ; Dennis W. Dicksona ; Owen A. Rossa ; e ; ross.owen@mayo.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Multiple system atrophy ; MAPT ; Association study ; Genetics
- 刊名：Parkinsonism & Related Disorders
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：30
- 期：Complete
- 页码：40-45
- 全文大小：260 K
文摘
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In this association study, we identified four MAPT haplotypes associated to MSA.
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Haplotype H2 and H1E are protective and H1x and H1J are risk haplotypes.
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The MAPT gene is involved in the susceptibility to MSA.
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Follow-up sequencing studies should be attempted to pinpoint causal variants.