Towards a nutritional approach for prevention of Alzheimer's disease: Biochemical and cellular aspects
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- 作者：Sabrina Florent-Bé ; chard ; Catherine Malaplate-Arm ; Violette Koziel ; Badreddine Kriem ; Jean-Luc Olivier ; Thierry Pillot ; Thierry Oster
- 关键词：Alzheimer's disease ; Docosahexaenoic acid ; Brain lipids ; Neuroprotection ; Aβ ; peptide
- 刊名：Journal of the Neurological Sciences
- 出版年：2007
- 出版时间：15 November 2007
- 年：2007
- 卷：262
- 期：1-2
- 页码：27-36
- 全文大小：867 K
文摘
Alzheimer's disease (AD) is a major public health concern in all countries. Although the precise cause of AD is still unknown, a growing body of evidence supports the notion that soluble amyloid β-peptide (Aβ) may be the proximate cause of synaptic injuries and neuronal death early in the disease. AD patients display lower levels of docosahexaenoic acid (DHA, C22:6 ; n-3) in plasma and brain tissues as compared to age-matched controls. Furthermore, epidemiological studies suggest that high DHA intake might have protective properties against neurodegenerative diseases. These observations are supported by in vivo studies showing that DHA-rich diets limits the synaptic loss and cognitive defects induced by Aβ peptide. Although the molecular basis of these neuroprotective effects remains unknown, several mechanisms have been proposed such as (i) regulation of the expression of potentially protective genes, (ii) activation of anti-inflammatory pathways, (iii) modulation of functional properties of the synaptic membranes along with changes in their physicochemical and structural features.