Crosstalk between Sentinel and Helper Macrophages Permits Neutrophil Migration into Infected Uroepithelium

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• 作者：Marzena Schiwon ; Christina Weisheit ; Lars Franken ; Sebastian Gutweiler ; Akanksha Dixit ; Catherine Meyer-Schwesinger ; Judith-Mira Pohl ; Nicholas聽J. Maurice ; Stephanie Thiebes ; Kristina Lorenz ; Thomas Quast ; Martin Fuhrmann ; Georg Baumgarten ; Martin聽J. Lohse ; Ghislain Opdenakker ; J眉rgen Bernhagen ; Rick Bucala ; Ulf Panzer ; Waldemar Kolanus ; Hermann-Josef Gr枚ne ; Natalio Garbi ; et al.
• 刊名：Cell
• 出版年：30 January, 2014
• 年：2014
• 卷：156
• 期：3
• 页码：456-468
• 全文大小：3836 K

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Summary

The phagocytes of the innate immune system, macrophages and neutrophils, contribute to antibacterial defense, but their functional specialization and cooperation is unclear. Here, we report that three distinct phagocyte subsets play highly coordinated roles in bacterial urinary tract infection. Ly6C^{鈭?/sup> macrophages acted as tissue-resident sentinels that attracted circulating neutrophils and Ly6C+ macrophages. Such Ly6C+ macrophages played a previously undescribed helper role: once recruited to the site of infection, they produced the cytokine TNF, which caused Ly6C鈭?/sup> macrophages to secrete CXCL2. This chemokine activated matrix metalloproteinase-9 in neutrophils, allowing their entry into the uroepithelium to combat the bacteria. In summary, the sentinel macrophages elicit the powerful antibacterial functions of neutrophils only after confirmation by the helper macrophages, reminiscent of the licensing role of helper T聽cells in antiviral adaptive immunity. These findings identify helper macrophages and TNF as critical regulators in innate immunity against bacterial infections in epithelia.}