Cationic cyclodextrin/alginate chitosan nanoflowers as 5-fluorouracil drug delivery system
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- 作者：Jaya R. Lakkakulaa ; b ; c ; spencerjaya@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Thabo Matshayaa ; thabo.matshaya@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Rui Werner Maç ; edo Krauseb ; r.krause@ru.ac.za" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cationic-β-cyclodextrin ; 5-Fluorouracil ; Nanoflowers ; Alginate ; Chitosan ; Inclusion complex and oral delivery system
- 刊名：Materials Science & Engineering C
- 出版年：2017
- 出版时间：1 January 2017
- 年：2017
- 卷：70
- 期：part_P1
- 页码：169-177
- 全文大小：2150 K
文摘
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Cationic-β-cyclodextrin polymer was synthesized and characterized.
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Inclusion complex was synthesized and studied using 1H NMR and 2D NMR, FTIR, DSC and SEM.
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Inclusion complex with cationic charge was crosslinked with Alginate and Chitosan to form nanoflowers.
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Particle size could be tailor made by adjusting chitosan concentration.
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Nanoflowers can serve as an ideal drug delivery system.