Sorption of structurally different ionized pharmaceutical and illicit drugs to a mixed-mode coated microsampler
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- 作者：Hester Peltenburga ; 1 ; H.Peltenburg@uu.nl" class="auth_mail" title="E-mail the corresponding author ; Niels Timmera ; 1 ; Ingrid J. Bosmanb ; Joop L.M. Hermensa ; Steven T.J. Drogea
- 关键词：Solid-phase microextraction ; Mixed-mode fiber ; Cation exchange ; C18/SCX ; Cationic compounds
- 刊名：Journal of Chromatography A
- 出版年：2016
- 出版时间：20 May 2016
- 年：2016
- 卷：1447
- 期：Complete
- 页码：1-8
- 全文大小：1000 K
文摘
- •
Sorption to the C18/SCX SPME fiber of a wide variety of drugs is studied.
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Sorption of cations without H
bonding capacity closely relates to their log Kow.- •
Sorption of cations with H
bonding capacity is underestimated by log Kow.- •
Performance of C18/SCX fibers is comparable to that of ion-exchange membranes.
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Explored the applicability domain of the C18/SCX fiber for organic cations.