Extracts from two ubiquitous Mediterranean plants ameliorate cellular and animal models of neurodegenerative proteinopathies

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• 作者：Michelle Briffa^a ; ^b ; ^c ; Stephanie Ghio^a ; ^c ; Johanna Neuner^a ; ¹ ; Alison J. Gauci^a ; Rebecca Cacciottolo^a ; ^c ; Christelle Marchal^b ; Mario Caruana^a ; ^c ; Christophe Cullin^b ; Neville Vassallo^a ; ^c ; Ruben J. Cauchi^a ; ^c ; ^{ruben.cauchi@um.edu.mt}
• 关键词：Neurodegenerative proteinopathies ; Opuntia ficus-indica extract ; Padina pavonica extract ; Amyloid-β (Aβ) peptide ; α-Synuclein (α-syn) protein ; Model organisms
• 刊名：Neuroscience Letters
• 出版年：2017
• 出版时间：18 January 2017
• 年：2017
• 卷：638
• 期：Complete
• 页码：12-20
• 全文大小：1864 K
• 卷排序：638

文摘

Extract of Padina pavonica (EPP) and Opuntia ficus-indica (EOFI) investigated. EOFI or EPP improved viability of a yeast model of Alzheimer’s disease (AD). EOFI or EPP treatment ameliorated lifespan and mobility defects in AD flies. Survival of Parkinson’s disease but not wild-type flies is enhanced by EOFI or EPP. Either extract mitigates toxicity of Amyloid-β and α-synuclein aggregates.