Two years changes in the development of caudate nucleus are involved in restricted repetitive behaviors in 2-5-year-old children with autism spectrum disorder

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• 作者：Ting Qiu^a ; ^c ; Chen Chang^a ; Yun Li^a ; Lu Qian^a ; Chao Yong Xiao^a ; Ting Xiao^a ; Xiang Xiao^a ; Yun Hua Xiao^a ; Kang Kang Chu^a ; Mark H. Lewis^b ; Xiaoyan Ke^a ; ^{kexynj@hotmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Magnetic resonance imaging ; Autism spectrum disorder ; Caudate nucleus development ; Restricted ; Repetitive behavior
• 刊名：Developmental Cognitive Neuroscience
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：19
• 期：Complete
• 页码：137-143
• 全文大小：971 K

文摘

Caudate nucleus volume is enlarged in autism spectrum disorder (ASD) and is associated with restricted and repetitive behaviors (RRBs). However, the trajectory of caudate nucleus volume in RRBs of young children remains unclear. Caudate nucleus volume was measured in 36 children with ASD and 18 matched 2–3-year-old subjects with developmentally delayed (DD) at baseline (Time 1) and at 2-year follow-up (Time 2). The differential growth rate in caudate nucleus volume was calculated. Further, the relationships between the development of caudate nucleus volume and RRBs were analyzed. Our results showed that caudate nucleus volume was significantly larger in the ASD group at both time points and the magnitude of enlargement was greater at Time 2. The rate of caudate nucleus growth during this 2-year interval was faster in children with ASD than DD. Right caudate nucleus volume growth was negatively correlated with RRBs. Findings from this study suggest developmental abnormalities of caudate nucleus volume in ASD. Longitudinal MRI studies are needed to explore the correlation between atypical growth patterns of caudate nucleus and phenotype of RRBs.