Levo-tetrahydropalmatine inhibits the acquisition of ketamine-induced conditioned place preference by regulating the expression of ERK and CREB phosphorylation in rats
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- 作者：Yan Dua ; c ; Li Dub ; Jie Caoc ; Christian Hö ; lscherd ; e ; Yongming Fengc ; Hongliang Suc ; Yujin Wangc ; cxddy_2004@sxmu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Ke-Ming Yunc
- 关键词：l-THP ; levo-tetrahydropalmatine ; ERK ; extracellular-regulated kinase ; CREB ; cAMP responsive element binding protein ; Hip ; hippocampus ; CPu ; caudate putamen ; PFc ; prefrontal cortex ; CPP ; conditioned place preference ; PCP ; phencyclidine ; NMDA ; N-methyl-d-aspartate
- 刊名：Behavioural Brain Research
- 出版年：2017
- 出版时间：15 January 2017
- 年：2017
- 卷：317
- 期：Complete
- 页码：367-373
- 全文大小：1262 K
文摘
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The drug l-THP attenuated the acquisition of ketamine-induced CPP in rats.
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l-THP prevented the increase in ERK phosphorylation in the Hip and CPu of the rats exhibiting CPP.
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l-THP decreased the phosphorylation of CREB in the Hip and CPu of the rats exhibiting CPP.
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l-THP may be a potential medicine for the treatment of ketamine addiction.