Predictive Factors of Lack of Response to Antiviral Therapy Among in Patients With Recurrent Hepatitis C After Liver Transplantation
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- 作者：M. Marino ; R.M. Iemmolo ; R. Montalti ; M. Bertolotti ; F. Di Benedetto ; N. De Ruvo ; N. Cautero ; G. Guerrini ; M.G. De Blasiis ; G.E. Gerunda
- 刊名：Transplantation Proceedings
- 出版年：2010
- 出版时间：May 2010
- 年：2010
- 卷：42
- 期：4
- 页码：1223-1225
- 全文大小：106 K
文摘
The current therapy for hepatitis C recurrence after liver transplantation OLT is based on interferon (IFN) and ribavirin (RBV) in monotherapy or combination. The rate of sustained virological response (SVR) varies between 10 % and 45 % . We have retrospectively analyzed factors that could predict SVR after antiviral therapy. We analyzed 42 patients who completed a cycle of therapy with natural or pegylated IFN plus RBV. There were 15 (35.7 % ) patients who obtained an SVR. The following factors were significantly associated with a lack of SVR: donor age ≥50 years (P = .046); donor body mass index (BMI) > 27 (P = .016); genotype 1 versus 2 to 3 (P = 0.010), aspartate transferase (AST) before therapy ≥ 140 U/L (P = .046), alanine transferase before therapy ≥ 280 U/L (P = .055), use of natural IFN versus pegylated IFN (P = .016). The only factors remaining after multivariate analysis were: donor BMI, AST before therapy and genotype. Our data confirmed that genotype 1 was associated with poorer outcomes; other additional parameters can influence the response to antiviral therapy.