The effect of N-acetylcysteine on biofilms: Implications for the treatment of respiratory tract infections

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• 作者：Francesco Blasi^a ; Clive Page^b ; Gian Maria Rossolini^c ; ^d ; ^e ; ^f ; Lucia Pallecchi^e ; Maria Gabriella Matera^g ; Paola Rogliani^h ; ⁱ ; Mario Cazzola^h ; ^{mario.cazzola@uniroma2.it" class="auth_mail" title="E-mail the corresponding author}
• 关键词：N-acetylcysteine ; Biofilm ; Airways infections ; Topical administration ; Inhaled formulation
• 刊名：Respiratory Medicine
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：117
• 期：Complete
• 页码：190-197
• 全文大小：1028 K

文摘

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d="p0010">Bacteria can be organized into biofilms accounting for most infections and are related to exacerbation or relapse of symptoms.

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d="p0015">Since antibiotics are not always effective in eradicating biofilms, there is an increased interest in non-antibiotic therapies.

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d="p0020">In vitro, NAC has good antibacterial properties and is able to interfere with biofilm formation and disrupt them.

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d="p0025">If clinical evidence will reinforce these data, NAC will be a good candidate for prevention and treatment of biofilms.

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d="p0030">The inhalation route might be considered a practical option for NAC.

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