SCG had higher total fiber and resistant starch content compared with coffee beans.
SCG can be fermented by colon microbiota producing short-chain fatty acids.
Human gut fermented-unabsorbed-SCG fraction suppress NO production.
Hgf-NDSCG modulates IL-10, CCL-17, CXCL9, IL-1β, and IL-5 cytokines.
SCG could protect the onset and/or progression of chronic inflammatory diseases.