Healthcare-associated Gram-negative bloodstream infections: antibiotic resistance and predictors of mortality

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• 作者：Ö ; . Ergö ; nü ; l^a ; ^{oergonul@ku.edu.tr} ; M. Aydin^b ; A. Azap^c ; S. Başaran^d ; S. Tekin^a ; Ş. Kaya^e ; S. Gü ; lsü ; n^e ; G. Yö ; rü ; k^f ; E. Kurşun^g ; A. Yeşilkaya^h ; F. Şimşekⁱ ; E. Yılmaz^j ; H. Bilgin^k ; &Ccedil ; . Hatipoğlu^l ; H. Cabadak^m ; Y. Tezer^m ; T. Toganⁿ ; İ. Karaoğlan^o ; A. İnan^p ; A. Engin^q ; H.E. Alışkan^g ; S.Ş. Yavuz^d ; Ş. Erdin&ccedil ; ^l ; L. Mulazimoglu^k ; Ö ; . Azap^h ; F. Can^a ; H. Akalın^j ; F. Timurkaynak^b ; Turkish Society of Clinical Microbiology ; Infectious Diseases ; Healthcare-Related Infections Study Group
• 关键词：Bloodstream ; Gram-negative ; Healthcare
• 刊名：Journal of Hospital Infection
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：94
• 期：4
• 页码：381-385
• 全文大小：213 K
• 卷排序：94

文摘

This article describes the prevalence of antibiotic resistance and predictors of mortality for healthcare-associated (HA) Gram-negative bloodstream infections (GN-BSI). In total, 831 cases of HA GN-BSI from 17 intensive care units in different centres in Turkey were included; the all-cause mortality rate was 44%. Carbapenem resistance in Klebsiella pneumoniae was 38%, and the colistin resistance rate was 6%. Multi-variate analysis showed that age >70 years [odds ratio (OR) 2, 95% confidence interval (CI) 1.22–3.51], central venous catheter use (OR 2.1, 95% CI 1.09–4.07), ventilator-associated pneumonia (OR 1.9, 95% CI 1.1–3.16), carbapenem resistance (OR 1.8, 95% CI 1.11–2.95) and APACHE II score (OR 1.1, 95% CI 1.07–1.13) were significantly associated with mortality.