THE EFFECT OF CHRONIC STRESS ON HEPATIC AND GASTRIC LIPID PEROXIDATION IN LONG-TERM DEPLETION OF GLUTATHIONE IN RATS

详细信息    查看全文

• 作者：SE&Ccedil ; KIN ; SULE ; ALPTEKIN ; NILGÜ ; N ; DOGRU-ABBASOGLU ; SEMRA ; KO&Ccedil ; AK-TOKER ; NECLA ; et. al.
• 刊名：Pharmacological Research
• 出版年：1997
• 出版时间：July, 1997
• 年：1997
• 卷：36
• 期：1
• 页码：55-57
• 全文大小：37.3 K

文摘

The effect of chronic stress (immobilization and cold) on hepatic and gastric thiobarbituric acid reactive substances (TBARS) and vitamin C levels were investigated in rats having long-term depletion of glutathione (GSH) by applying buthionine sulfoximine (BSO). GSH and vitamin C levels decreased and TBARS levels increased in the liver and stomach of rats subjected to stress. Long-term BSO administration along with stress caused no additional changes in these parameters. These results may indicate that long-term glutathione depletion did not potentiate stress-induced hepatic and gastric lipid peroxidation.