Infusion of exogenous cholecystokinin-8, gastrin releasing peptide-29 and their combination reduce body weight in diet-induced obese male rats

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• 作者：Thaer R. Mhalhal ; Martha C. Washington ; Kayla Newman ; John C. Heath ; Ayman I. Sayegh ; ^{sayeghai@mytu.tuskegee.edu}
• 关键词：Cholecystokinin-8 ; Gastrin releasing Peptide-29 ; Body weight ; Aorta ; Diet-induced obese rats
• 刊名：Appetite
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：109
• 期：Complete
• 页码：172-181
• 全文大小：2522 K
• 卷排序：109

文摘

We hypothesized that exogenous gastrin releasing peptide-29 (GRP-29), cholecystokinin-8 (CCK-8) and their combination reduce body weight (BW). To test this hypothesis, BW was measured in four groups of diet-induced obese (DIO) male rats infused in the aorta (close to the junctions of the celiac and cranial mesenteric arteries) with saline, CCK-8 (0.5 nmol/kg), GRP-29 (0.5 nmol/kg) and CCK-8+GRP-29 (0.5 nmol/kg each) once daily for a total of 23 days. We found that CCK-8, GRP-29 and CCK-8+GRP-29 reduce BW relative to saline control. In conclusion, CCK-8, GRP-29 and their combination reduce BW in the DIO rat model. If infused near their gastrointestinal sites of action CCK-8, GRP-29 and their combination may have a role in regulating BW.