Neuroprotective effects of pterostilbene against oxidative stress injury: Involvement of nuclear factor erythroid 2-related factor 2 pathway
详细信息 查看全文
- 作者：Bodong Wanga ; 1 ; Haixiao Liua ; 1 ; Liang Yuea ; 1 ; Xia Lia ; Lei Zhaoa ; Xiangmin Yanga ; Xinchuan Wanga ; Yang Yanga ; b ; Yan Qua ; yanqu0123@fmmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：ANOVA ; analysis of variance ; ARE ; antioxidant response element ; CCK8 ; Cell Counting Kit-8 ; CO ; carbon monoxide ; DAPI ; 4&prime ; 6-diamino-2-phenylindole ; DMEM ; Dulbecco's modified Eagle's medium ; DMSO ; dimethylsulfoxide ; ERK ; extracellular regulated kinase ; FBS ; fetal bovine serum ; GSH ; glutathione ; GST ; glutathione S-transferase ; H2-DCF-DA ; 2&prime ; 7&prime ; -dichlorofluorescin diacetate ; HO-1 ; heme oxygenase-1 ; IR ; ischemia reperfusion ; IRI ; ischemia reperfusion injury ; LDH ; lactate dehydrogenas
- 刊名：Brain Research
- 出版年：2016
- 出版时间：15 July 2016
- 年：2016
- 卷：1643
- 期：Complete
- 页码：70-79
- 全文大小：3976 K
文摘
- •
Pterostilbene is non-toxic to HT22 neurons.
- •
The anti-oxidative stress effect of pterostilbene on HT22 cells is proposed.
- •
The anti-apoptosis effect of pterostilbene on HT22 cells is proposed.
- •
The mechanism relies on nuclear translocation of Nrf2.
- •
Upregulation of HO-1 and NQO1 is involved in the mechanism.