Specific binding of a mutated fragment of Clostridium perfringens enterotoxin to endothelial claudin-5 and its modulation of cerebral vascular permeability
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- 作者：Zhuangbin Liaoa ; &dagger ; ; Zhenguo Yanga ; &dagger ; ; Anna Piontekb ; Miriam Eichnerc ; Gerd Krauseb ; Longxuan Lid ; Joerg Piontekc ; Jingjing Zhanga ; jingjing.zhang@live.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：BBB ; blood&ndash ; brain barrier ; cCPE ; Clostridium perfringens enterotoxin ; TEER ; transendothelial electrical resistance
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：7 July 2016
- 年：2016
- 卷：327
- 期：Complete
- 页码：53-63
- 全文大小：4150 K
文摘
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Drug delivery to the central nervous system is limited by the blood–brain barrier (BBB).
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The Clostridium perfringens enterotoxin fragment cCPEY306W/S313H binds to claudin-5 of the BBB.
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cCPEY306W/S313H reversibly increases paracellular permeability of in vitro- and zebrafish BBB models.
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We suggest cCPEY306W/S313H as a tight junction modulator to improve drug delivery across the BBB.