Mechanisms underlying the hyperalgesic responses triggered by joint activation of TLR4
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- 作者：Ana T.G. Guerreroa ; b ; 3 ; anaguerrero@fiocruz.br" class="auth_mail" title="E-mail the corresponding author ; Larissa G. Pintoa ; 1 ; 3 ; larifarm@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Fernando Q. Cunhaa ; fdqcunha@fmrp.usp.br" class="auth_mail" title="E-mail the corresponding author ; Sé ; rgio H. Ferreiraa ; 2 ; shferrei@fmrp.usp.br" class="auth_mail" title="E-mail the corresponding author ; Jose C. Alves-Filhoa ; jcafilho@usp.br" class="auth_mail" title="E-mail the corresponding author ; Waldiceu A. Verri Jr.c ; waldiceujr@yahoo.com.br" class="auth_mail" title="E-mail the corresponding author ; waverri@uel.br" class="auth_mail" title="E-mail the corresponding author ; Thiago M. Cunhaa ; thicunha@usp.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：AIA ; antigen-induced arthritis ; C3 ; complement component 3 ; CIA ; collagen-induced arthritis ; COX ; cyclooxygenase ; CXCR1/2 ; CXC chemokine receptors type 1 and 2 ; DAMPs ; damage-associated molecular patterns ; DRG ; dorsal root ganglion ; ELISA ; enzyme-linked immunosorbent assay ; ia ; intra-articular ; IFN ; interferon ; IL ; interleukin ; IL-1R1 ; IL-1 receptor type 1 ; IRF ; IFN-regulatory factor ; KC/CXCL1 ; keratinocyte chemoattractant/chemokine (CXC) ligand 1 ; KO ; Knockout ; LPS ; lipopolysaccharide ; MPO ; mye
- 刊名：Pharmacological Reports
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：68
- 期：6
- 页码：1293-1300
- 全文大小：813 K
文摘
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Joint activation of TLR4 causes a dose- and time-dependent hyperalgesia.
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Joint hyperalgesia caused by TLR4 activation depends on MYD88 signaling.
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This pathway leads to joint hyperalgesia through mechanisms dependent on cytokines and chemokines production.
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TLR4/MyD88 signaling pathway inhibitors might be useful for the treatment of inflammatory joint pain.