Characterization of clinical and immunological features in patients coinfected with dengue virus and HIV
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- 作者：Amanda Torrentes-Carvalhoa ; biotorrentes@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Eugê ; nio Damaceno Hottzb ; Cintia Ferreira Marinhoa ; Jé ; ssica Badolato-Corrê ; a da Silvaa ; Luzia Maria de Oliveira Pintoa ; Luciana Gomes Fialhoa ; Fernando Augusto Bozzab ; Rivaldo Venâ ; ncio Cunhac ; Paulo Vieira Damascod ; Claire Fernandes Kubelkaa ; Elzinandes Leal de Azeredoa ; elzinandes@ioc.fiocruz.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：AIDS ; Acquired Immunodeficiency Syndrome ; Ag ; antigen ; ANOVA ; analysis of variance ; APC ; antigen-presenting cell ; APC-Cy7 ; Allophycocyanin conjugated cyanine dye ; BSA ; bovine serum albumin ; CD ; cluster of differentiation ; Cy ; cycrome ; DENV ; dengue virus ; DF ; dengue fever ; DHF/DSS ; dengue hemorrhagic fever or shock syndrome ; DMSO ; dimethyl sulfoxide ; ELISA ; enzyme-linked immunosorbent assay ; FACS ; fluorescence-activated cell sorting ; FBS ; fetal bovine serum ; FITC ; fluorescein isothiocyanate ; HIV
- 刊名：Clinical Immunology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：164
- 期：Complete
- 页码：95-105
- 全文大小：992 K
文摘
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Diagnosis of severe dengue was less frequent in DENV/HIV coinfection.
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Coinfected patients presented low CD4+ T cells% with increased in CCR5 expression.
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An increased CD107a expression on both T subsets was observed during coinfection.
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Chemokines IP-10 and IL-8 were significantly altered in plasma of coinfected patients.
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Cytokines involved in dengue pathogenesis were also increased during coinfection.