Treg with stable and unstable Foxp3 expression might regulate the immune system.
Both types of Treg can express IFNy and both IFNy- and IFNy+ Treg appear to have clinical relevance.
They modulate effector cells via TGFß, CTLA4, perforin, FasL and consumption of IFNy and IL2.
We believe that these Treg modulate alloreactivity of T- and B-lymphocytes as well as NK cells.
We believe that they have a potential of allowing reduction of immunosuppressive drugs to low maintenance levels.