Pharmacological inhibition of AKT activity in human CD34⁺ cells enhances their ability to engraft immunodeficient mice

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• 作者：Sisi Chen^a ; Rui Gao^b ; Michihiro Kobayashi^b ; Hao Yu^b ; Chonghua Yao^c ; Reuben Kapur^b ; Mervin C. Yoder^b ; Yan Liu^a ; ^b ; ^{liu219@iu.edu}
• 刊名：Experimental Hematology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：45
• 期：Complete
• 页码：74-84
• 全文大小：2089 K
• 卷排序：45

文摘

Inhibition of AKT increases human CD34+ cell quiescence. Inhibition of AKT enhances the colony formation potential of human CD34+ cells. Pharmacological inhibition of AKT enhances the engraftment of HSPCs in vivo.