Parkin Regulates Mitosis and Genomic Stability through Cdc20/Cdh1
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- 作者：Seung Baek Lee1 ; 13 ; Jung Jin Kim1 ; 13 ; Hyun-Ja Nam2 ; Bowen Gao1 ; Ping Yin1 ; Bo Qin1 ; Sang-Yeop Yi3 ; Hyoungjun Ham4 ; 5 ; Debra Evans1 ; 5 ; 6 ; Sun-Hyun Kim7 ; Jun Zhang8 ; Min Deng1 ; Tongzheng Liu1 ; Haoxing Zhang1 ; Daniel D. Billadeau4 ; 9 ; Liewei Wang10 ; Emilie Giaime11 ; Jie Shen11 ; Yuan-Ping Pang10 ; Jin Jen12 ; Jan M. van Deursen2 ; 6 ; Zhenkun Lou1 ; lou.zhenkun@mayo.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Molecular Cell
- 出版年：2015
- 出版时间：1 October 2015
- 年：2015
- 卷：60
- 期：1
- 页码：21-34
- 全文大小：5077 K
文摘
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The Parkin-Cdc20/Cdh1 complex is an important mitotic regulator
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The Parkin-Cdc20/Cdh1 complex is independent of the APC/C-Cdc20/Cdh1 complex
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Parkin is phosphorylated and activated by Plk1
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Parkin maintains genomic stability and is a tumor suppressor