Structural and biological function of NYD-SP15 as a new member of cytidine deaminases
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- 作者：Yidan Xua ; Lei Lib ; Jianmin Lia ; JIANMINLI@yeah.net" class="auth_mail" title="E-mail the corresponding author ; Qinghuai Liua
- 关键词：CDAs ; cytidine deaminases ; C ; cytidine ; U ; uridine ; dCMP DA ; deoxycytidine deaminase ; AID ; activated induced deaminase ; APOBEC ; apoB mRNA editing cytidine deaminase ; DMEM ; Dulbecco's Modified Eagle Medium ; FBS ; fetal bovine serum ; NLS ; nucleus located signal sequence ; NES ; nucleus export signal sequence ; Rif R ; rifampicin resistance ; IPTG ; inducer isopropylthiogalactoside ; C ; cytoplasmic ; N ; nuclear ; N/C ; scatter ; PCDD1 ; P133 in CDD1 ; PCDD2 ; P390 in CDD2
- 刊名：Gene
- 出版年：2016
- 出版时间：25 May 2016
- 年：2016
- 卷：583
- 期：1
- 页码：36-47
- 全文大小：2244 K
文摘
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NYD-SP15 was closely related to deoxycytolyte deaminase and cytidine deaminase.
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NYD-SP15 contained NLS and NES and could dynamically shuttle between the nucleus and cytoplasm.
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NYD-SP15 gene over-expression reduced the cell growth and blocked G1 to S phase.