This is the first report revealing the anti-tumor bioactivity of M11 on A549 and A549/CDDP cells. And A549/CDDP cells are about 100 times more sensitive than A549 cells to M11 treatment.
M11 induces cell cycle arrest at the G2/M phase in A549/CDDP cells.
M11 triggers JNK-mediated apoptosis via the mitochondrial apoptotic pathway in A549/CDDP cells.