Cdh23erl/erl mutant mouse is an established model of genetic hearing loss.
Tauroursodeoxycholic acid (TUDCA) has been used in diseases related to apoptosis.
We studied otoprotective effects and mechanisms of TUDCA in Cdh23erl/erl mice.
TUDCA protects against hearing loss and hair cell death in Cdh23erl/erl mice.
TUDCA partly inhibits the intrinsic apoptosis in Cdh23erl/erl mouse cochleae.