Synthesis and immunostimulatory properties of the phosphorothioate analogues of cdiGMP
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- 作者：Hongbin Yan ; Xiaolu Wang ; Rhonda KuoLee ; Wangxue Chen
- 关键词：cdiGMP ; Vaccine adjuvant ; Immunostimulation ; Phosphorothioate
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：2008
- 出版时间：15 October 2008
- 年：2008
- 卷：18
- 期：20
- 页码：5631-5634
- 全文大小：318 K
文摘
The synthesis of mono- and bisphosphorothioate analogues of 3′,5′-cyclic diguanylic acid (cdiGMP) via the modified H-phosphonate chemistry is reported. The immunostimulatory properties of these analogues were compared with those of cdiGMP.