Molecular characterization and expression analyses of cDNAs encoding the thioredoxin-interacting protein and selenoprotein P genes and histological changes in Nile tilapia (Oreochromis niloticus) in response to silver nanoparticle exposure
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- 作者：Kubpaphas Thummabanchaa ; Nuttaphon Onparnb ; Prapansak Srisapoomec ; ffispssp@ku.ac.th" class="auth_mail" title="E-mail the corresponding author
- 关键词：Ag NPs ; silver nanoparticles ; On-TXNIP ; Nile tilapia thioredoxin-interacting protein ; On-SEPP ; Nile tilapia selenoprotein P ; cDNAs ; complementary deoxynucleic acids ; real-time qRT-PCR ; real-time quantitative reverse transcription polymerase chain reaction
- 刊名：Gene
- 出版年：2016
- 出版时间：15 February 2016
- 年：2016
- 卷：577
- 期：2
- 页码：161-173
- 全文大小：3002 K
文摘
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Nile tilapia thioredoxin interacting protein (On-TXNIP) & selenoprotein P (On-SEPP) cDNAs were completely characterized.
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Significant up-regulation of On-TXNIP and On-SEPP transcripts was observed at early phase of Ag NP exposure.
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Down-regulation of On-SEPP mRNA was found in the liver at weeks 1–4 after fish exposed to Ag NPs.
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Histopathological changes of liver in Ag NP-exposed fish increased in Kupffer cell infiltration and blood congestion.