Distinct mechanisms for opposite functions of homeoproteins Cdx2 and HoxB7 in double-strand break DNA repair in colon cancer cells
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- 作者：Christine Soreta ; b ; Elisabeth Martina ; b ; Isabelle Duluca ; b ; Franç ; oise Dantzerb ; c ; Marie Vaniera ; b ; Isabelle Grossa ; b ; Jean-Noë ; l Freunda ; b ; Claire Domon-Della ; b ; Claire.domon@inserm.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Homeobox gene ; Transcription ; Nontranscriptional ; KU complex
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：1 May 2016
- 年：2016
- 卷：374
- 期：2
- 页码：208-215
- 全文大小：2321 K
文摘
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HoxB7 and Cdx2 have different expression profiles in normal and cancerous intestinal epithelium.
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Cdx2 and HoxB7 exert opposite effects on DNA repair activity, using respectively non transcriptional and transcriptional mechanisms.
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As in breast cancer cells, HoxB7 stimulates DNA repair.
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Cdx2 counteracts HoxB7 transcriptional activity through direct or indirect interaction.