The analysis of novel distal Cebpa enhancers and silencers using a transcriptional model reveals the complex regulatory logic of hematopoietic lineage specification
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- 作者：Eric Bertolinoa ; eric.bertolino@gmail.com" class="auth_mail" title="E-mail the corresponding author ; John Reinitza ; b ; c ; Manuc ; d ; 1 ; manu.manu@und.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cell fate ; Gene regulation ; Hematopoiesis ; Silencers ; Transcriptional modeling
- 刊名：Developmental Biology
- 出版年：2016
- 出版时间：1 May 2016
- 年：2016
- 卷：413
- 期：1
- 页码：128-144
- 全文大小：2409 K
文摘
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A novel experimental-computational method for cis-regulatory decoding
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Distal silencers outnumber enhancers in the Cebpa locus
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Non-myeloid transcription factors GATA and EBF1 repress Cebpa by binding silencers
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Cebpa is activated via enhancers by C/EBP family TFs, PU.1, Ets1, and Egr1