The PD-L1/CD86 ratio is increased in dendritic cells co-infected with porcine circovirus type 2 and porcine reproductive and respiratory syndrome virus, and the PD-L1/PD-1 axis is associated with anergy, apoptosis, and the induction of regulatory T-cells in porcine lymphocytes
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- 作者：O. Richmond ; T.E. Cecere<sup> ; sup><sup>tcecere@vt.edu" class="auth_mail" title="E-mail the corresponding authorsup> ; E. Erdogan ; X.J Meng ; P. Piñ ; eyro ; S. Subramaniam ; S.M. Todd ; T. LeRoith
- 关键词：Porcine circovirus type 2 (PCV2) ; Porcine circovirus associated disease (PCVAD) ; Porcine reproductive and respiratory syndrome virus (PRRSV) ; Co-infection ; Programed death ligand-1 (PD-L1) ; Programed cell death-1 (PD-1) ; Monocyte derived dendritic cells (MoDC)
- 刊名：Veterinary Microbiology
- 出版年：2015
- 出版时间：18 November 2015
- 年：2015
- 卷：180
- 期：3-4
- 页码：223-229
- 全文大小：904 K
文摘
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PD-L1 expression is increased in dendritic cells following PCV2/ PRRSV co-infection.
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CD86 expression is decreased in dendritic cells following PCV2/PRRSV co-infection.
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IL-10 expression is increased in dendritic cells following PCV2 /PRRSV co-infection.
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The PD-L1/PD-1 axis causes apoptosis, anergy, and the induction of regulatory T-cells.
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This data provides potential mechanisms in PCVAD pathogenesis.