Cipura paludosa attenuates long-term behavioral deficits in rats exposed to methylmercury during early development

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• 作者：Greice M.R.S. Lucena ; Fá ; bio A. Porto ; É ; lida G. Campos ; Mariangela S. Azevedo ; Valdir Cechinel-Filho ; Rui D.S. Prediger ; Vania M.M. Ferreira
• 关键词：Cipura paludosa ; Cognitive functions ; Oxidative stress ; HPLC ; Methylmercury ; Naphthoquinones
• 刊名：Ecotoxicology and Environmental Safety
• 出版年：2010
• 出版时间：September 2010
• 年：2010
• 卷：73
• 期：6
• 页码：1150-1158
• 全文大小：512 K

文摘

In the present study, we evaluated the effects of the ethanolic extract (EE) of Cipura paludosa on locomotor, and anxiety- and depression-like behaviors of adult rats exposed to MeHg during early development. Additionally, the antioxidant enzymes catalase (CAT) and selenium-glutathione peroxidase (Se-GPx) were measured in cortical, hippocampal, and cerebellar tissues. Pregnant Wistar rats were treated by gavage with a single dose of MeHg (8 mg/kg) on gestational day 15, the developmental stage critical for cortical neuron proliferation. Moreover, prenatal MeHg exposure inhibited CAT and Se-GPx in the cortex and cerebellum. Chronic treatment with the EE of C. paludosa attenuated these emotional and antioxidant deficits induced by prenatal MeHg toxic exposure. This study provides novel evidence that developmental exposure to MeHg can affect not only cognitive functions but also locomotor, and anxiety- and depression-like behaviors .