A data-based exploration of the adverse outcome pathway for skin sensitization points to the necessary requirements for its prediction with alternative methods
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- 作者：Romualdo Benigni ; Romualdo.benigni@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Cecilia Bossa ; Olga Tcheremenskaia
- 关键词：Skin sensitization ; Alternative ; Human health ; Modeling ; QSAR ; Structure-activity ; Prediction ; Adverse outcome pathways
- 刊名：Regulatory Toxicology and Pharmacology
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：78
- 期：Complete
- 页码：45-52
- 全文大小：713 K
文摘
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A detailed reanalysis of published data on skin sensitization is presented.
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Both in vitro and QSAR approaches can provide satisfactory predictions.
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Exploration and modeling of haptenation may ensure further progress.