Humoral innate immunity at the crossroad between microbe and matrix recognition: The role of PTX3 in tissue damage

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• 作者：Andrea Doni^a ; Giovanna D'Amico^b ; Diego Morone^a ; Alberto Mantovani^a ; ^c ; ^{alberto.mantovani@humanitasresearch.it} ; Cecilia Garlanda^a
• 关键词：Tissue repair ; Innate immunity ; Inflammation ; Pattern recognition molecule ; Pentraxin-3 (PTX3)
• 刊名：Seminars in Cell & Developmental Biology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：61
• 期：Complete
• 页码：31-40
• 全文大小：2672 K
• 卷排序：61

文摘

Innate immunity is involved in regulating inflammatory and tissue repair responses to injury. In particular, humoral innate immunity plays functions related to wound clearance from tissue debris, and regulation of macrophage and stromal cell activities. PTX3, a component of humoral innate immunity, orchestrates tissue repair by interacting with plasminogen and fibrin. Fluid-phase molecules of innate immunity interact with elements of the extracellular matrix, and some of the latter display opsonic activity against certain bacterial species.Thus, recognition of extracellular matrix and microbial components is a recurrent theme in the humoral arm of the innate immune system.