Synchronous occurrence of squamous-cell carcinoma “transformation” and EGFR exon 20 S768I mutation as a novel mechanism of resistance in EGFR-mutated lung adenocarcinoma
The synchronous occurrence of SCC “transformation” and exon 20 S768I is described. SCC transformation and exon 20 S768I is an unreported mechanism of resistance. This situation is challenging for clinicians in the choice of a second line therapy.