Assessment of postoperative local and distant recurrence in colorectal cancer patients: Comparison between PET/CT and CECT

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• 作者：Ahmed Mohamed Hussein ; ^{ahmed_hussein99@yaho.com" class="auth_mail" title="E-mail the corresponding author} ; Mohamed Amin Nassef¹ ; ^{drmanassef@yahoo.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Cancer colon ; 18F-FDG PET/CT ; Recurrence
• 刊名：The Egyptian Journal of Radiology and Nuclear Medicine
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：47
• 期：2
• 页码：431-438
• 全文大小：2151 K

文摘

To assess the diagnostic performance of 18F-FDG PET/CT scan in the detection of recurrent disease in CRC patients who have suspected local and/or distant recurrent disease compared to contrast enhanced CT scan (CECT).

Material and method

96 CRC treated patients with suspected recurrence were examined by CECT and 18F-FDG PET/CT. Pathological results, clinical or imaging follow-up, or the responsiveness of the lesion to the treatment with chemotherapy or radiation therapy were reviewed for gold standard.

Results

Recurrent or metastatic disease was found in 74 (77.1%) of 96 patients. Calculated sensitivity, specificity, and accuracy of 18F-FDG PET/CT were 92%, 72.7%, and 88.5%. The specificity of 18F-FDG PET/CT was statistically significantly better than that of CECT as it can reduce the false positive results of CECT in 13 patients, however regarding the sensitivity.

18F-FDG PET/CT showed better value but without statistical significance.

Conclusion

18F-FDG PET/CT is a better method to evaluate postoperative CRC patients with suspected tumor recurrence or distant metastasis than CT with significantly higher specificity.