RECQL4 Promotes DNA End Resection in Repair of DNA Double-Strand Breaks
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- 作者：Huiming Lu1 ; 4 ; Raghavendra A. Shamanna1 ; 4 ; Guido Keijzers2 ; Roopesh Anand3 ; Lene Juel Rasmussen2 ; Petr Cejka3 ; Deborah L. Croteau1 ; Vilhelm A. Bohr1 ; 2 ; vbohr@nih.gov" class="auth_mail" title="E-mail the corresponding author
- 关键词：RECQL4 ; Rothmund-Thomson syndrome ; DNA resection ; homologous recombination ; DNA repair ; RecQ-like helicase
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：28 June 2016
- 年：2016
- 卷：16
- 期：1
- 页码：161-173
- 全文大小：4264 K
文摘
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RECQL4 promotes 5′ end resection at DSBs
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RECQL4 recruitment to DSBs depends on MRE11
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RECQL4 promotes recruitment of CtIP to DSBs
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RECQL4 helicase activity is required for 5′ DNA end resection