Xrs2 Dependent and Independent Functions of the Mre11-Rad50 Complex
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- 作者：Julyun Oh1 ; 2 ; Amr Al-Zain1 ; 2 ; Elda Cannavo3 ; Petr Cejka3 ; Lorraine S. Symington2 ; 4 ; lss5@cumc.columbia.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Mre11 ; Rad50 ; Xrs2 ; Sae2 ; end resection ; homologous recombination ; DNA repair
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：20 October 2016
- 年：2016
- 卷：64
- 期：2
- 页码：405-415
- 全文大小：2512 K
文摘
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Xrs2 is not required for nuclease-associated functions of the Mre11-Rad50 complex
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Xrs2 independent end resection requires Sae2
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Tel1 recruitment to DSBs requires Xrs2
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Xrs2 is essential for canonical non-homologous end joining