Phosphorylated CtIP Functions as a Co-factor of the MRE11-RAD50-NBS1 Endonuclease in DNA End Resection

详细信息    查看全文

• 作者：Roopesh Anand¹ ; ² ; Lepakshi Ranjha¹ ; ² ; Elda Cannavo¹ ; ² ; Petr Cejka¹ ; ² ; ³ ; ^{petr.cejka@irb.usi.ch}
• 关键词：helicase ; nuclease ; homologous recombination ; DNA end resection ; double-strand DNA break
• 刊名：Molecular Cell
• 出版年：2016
• 出版时间：1 December 2016
• 年：2016
• 卷：64
• 期：5
• 页码：940-950
• 全文大小：2841 K
• 卷排序：64

文摘

Phosphorylated CtIP promotes the endonuclease of MRE11-RAD50-NBS1 The cleavage is dependent on the nuclease of MRE11 and the ATPase of RAD50 NBS1 and CtIP have structural roles to promote DNA cleavage by MRE11-RAD50 The endonuclease preferentially cleaves 5′ DNA strands near protein adducts