Reducing persistent polyomavirus infection increases functionality of virus-specific memory CD8 T cells

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• 作者：Qingsong Qin ; Matthew Lauver ; Saumya Maru ; Eugene Lin ; Aron E. Lukacher ; ^{alukacher@hmc.psu.edu}
• 关键词：Polyomavirus ; CD8 T cells ; Memory ; Persistent viral infection ; Mouse
• 刊名：Virology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：502
• 期：Complete
• 页码：198-205
• 全文大小：1024 K
• 卷排序：502

文摘

Construction of a recombinant mouse polyomavirus (MuPyV) carrying two loxP sites. Cre recombinase expression reduces acute and persistent infection levels of MuPyV-loxP. Expansion of virus-specific CD8 T cells is blunted with Cre induction in acutely infected mice. Cre induction in persistently infected mice improves memory CD8 T cell recall responses.