Association of functional genetic variants of transcription factor Forkhead Box P3 and Nuclear Factor-κB with end-stage renal disease and renal allograft outcome
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- 作者：Maneesh Kumar Misraa ; b ; Aditi Mishraa ; Shashi Kant Pandeyb ; Rakesh Kapoorc ; Raj Kumar Sharmad ; Suraksha Agrawala ; sur_ksha_agrawal@yahoo.co.in" class="auth_mail" title="E-mail the corresponding author ; suraksha@sgpgi.ac.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：° ; C ; degree celsius ; AP-1 ; activator protein-1 ; ARE ; acute rejection episode ; CCDC22 ; coiled-coil domain containing 22 ; EDTA ; ethylene diamine tetra acetic acid ; ESRD ; end stage renal disease ; FOXP3 ; Forkhead Box P3 ; GATA-3 ; GATA-binding protein-3 ; GD ; Grave's disease ; HWE ; Hardy&ndash ; Weinberg equilibrium ; IL-2Rβ ; interleukin-2Rβ ; LD ; linkage disequilibrium ; MAF ; minor allele frequency ; matSpD ; matrix spectral decomposition ; MDR ; multifactor dimensionality reduction ; MIM ; mammalian inheritan
- 刊名：Gene
- 出版年：2016
- 出版时间：25 April 2016
- 年：2016
- 卷：581
- 期：1
- 页码：57-65
- 全文大小：594 K
文摘
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FOXP3 SNPs rs2232365 and rs3761548 showed 3- to 3.5-folds risk for ESRD and ARE
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NF-kB1 SNPs rs28362491 and rs696 showed 2- to 4-folds risk for ESRD and ARE
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MDR analysis (six factor) revealed 6-folds risk for ESRD and 23-folds risk for ARE
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rs2232365, rs3761548, rs28362491 and rs696 SNPs showed lowest overall survival
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Moderate LD exists between rs2232365, rs3761548, rs5902434 and rs2294021 tag-SNPs