MUC1 expression in canine malignant mammary tumours and relationship to clinicopathological features

详细信息    查看全文

• 作者：Joana T. de Oliveira ; Salomé ; S. Pinho ; Augusto J. de Matos ; Venceslau Hespanhol ; Celso A. Reis ; Fá ; tima Gä ; rtner
• 关键词：MUC1 ; Mammary tumours ; Canine ; Metastasis
• 刊名：The Veterinary Journal
• 出版年：2009
• 出版时间：December 2009
• 年：2009
• 卷：182
• 期：3
• 页码：491-493
• 全文大小：353 K

文摘

Mucin-1 (MUC1) is over-expressed in human breast carcinomas and is linked to a poorer prognosis. In this study, MUC1 expression in 32 spontaneous canine malignant mammary tumours was characterised in relation to histological type, mode of growth, grade, lymph node metastases and distant metastases. All tumours exhibited immunostaining for MUC1. In the normal canine mammary gland, MUC1 was expressed mainly in the apical cellular membrane, while in carcinomas MUC1 was detected in the cytoplasm only (56.3 % ) or in the cytoplasm with membrane accentuation (43.7 % ). There was a significant association between development of distant metastases and MUC1 over-expression (P = 0.03), but no association with histological type, histological grade, mode of growth or lymph node metastasis.