Epithelial E- and P-cadherins: Role and clinical significance in cancer
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- 作者：Joana Paredes ; Joana Figueiredo ; Andr¨¦ Albergaria ; Patr¨ªcia Oliveira ; Joana Carvalho ; Ana Sofia Ribeiro ; Joana Caldeira ; ?ngela Margarida Costa ; Joana Sim?es-Correia ; Maria Jos¨¦ Oliveira ; Hugo Pinheiro ; Salom¨¦ S. Pinho ; Rita Mateus ; Celso A. Reis ; Marina Leite ; Maria Sofia Fern ; es ; Fern ; o Schmitt ; F¨¢tima Carneiro ; C¨¦u Figueiredo ; Carla Oliveira ; et al.
- 关键词：E-cadherin ; P-cadherin ; Cancer ; Gastric ; Breast ; Hereditary diffuse gastric cancer
- 刊名：Biochimica et Biophysica Acta (BBA)/Reviews on Cancer
- 出版年：2012
- 出版时间：December, 2012
- 年：2012
- 卷：1826
- 期：2
- 页码：297-311
- 全文大小：1188 K
文摘
E-cadherin and P-cadherin are major contributors to cell-cell adhesion in epithelial tissues, playing pivotal roles in important morphogenetic and differentiation processes during development, and in maintaining integrity and homeostasis in adult tissues. It is now generally accepted that alterations in these two molecules are observed during tumour progression of most carcinomas. Genetic or epigenetic alterations in E- and P-cadherin-encoding genes (CDH1 and CDH3, respectively), or alterations in their proteins expression, often result in tissue disorder, cellular de-differentiation, increased invasiveness of tumour cells and ultimately in metastasis. In this review, we will discuss the major properties of E- and P-cadherin molecules, its regulation in normal tissue, and their alterations and role in cancer, with a specific focus on gastric and breast cancer models.