Gastric cancer: adding glycosylation to the equation
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- 作者：Salom茅 S. Pinho ; S ; ra Carvalho ; Ricardo Marcos-Pinto ; Ana Magalh茫es ; Carla Oliveira ; Jianguo Gu ; M谩rio Dinis-Ribeiro ; F谩tima Carneiro ; Raquel Seruca ; Celso A. Reis
- 关键词：cancer ; gastric cancer ; glycosylation ; e-cadherin ; integrins ; biomarkers
- 刊名：Trends in Molecular Medicine
- 出版年：November, 2013
- 年：2013
- 卷：19
- 期：11
- 页码：664-676
- 全文大小：2488 K
文摘
Gastric cancer has a high incidence and mortality, so there is a pressing need to understand the underlying molecular mechanisms in order to discover novel biomarkers. Glycosylation alterations are frequent during gastric carcinogenesis and cancer progression. This review describes the role of glycans from the initial steps of the carcinogenesis process, in which Helicobacter pylori adheres to host mucosa glycans and modulates the glycophenotype, as well as how glycans interfere with epithelial cell adhesion by modulating epithelial cadherin functionality in gastric cancer progression. Other mechanisms regulating gastric cancer malignant behavior are discussed, such as increased sialylation interfering with key signaling pathways and integrin glycosylation leading to an invasive phenotype. Applications of these glycosylation alterations in the clinical management of gastric cancer patients are discussed.