Insights into the central pathways involved in the emetic and behavioural responses to exendin-4 in the ferret

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• 作者：Zengbing Lu^a ; Chi-Kong Yeung^a ; Ge Lin^a ; David T.W. Yew^a ; P.L.R. Andrews^c ; John A. Rudd^a ; ^b ; ^{jar@cuhk.edu.hk}
• 关键词：AP ; area postrema ; Arc ; arcuate nucleus ; BBB ; blood brain barrier ; BIN ; behaviours indicative of &ldquo ; nausea&rdquo ; BNST ; bed nucleus of the stria terminalis ; CC ; cingulate cortex ; CeA ; central nucleus of amygdala ; CSF ; cerebrospinal fluid ; DHM ; dorsal medial nucleus of hypothalamus ; Ex-4 ; exendin-4 ; Ex-(9&ndash ; 39) ; exendin-(9&ndash ; 39) ; GLP-1 ; glucagon-like peptide-1 ; ICC ; interstitial cells of Cajal ; i.c.v. ; intracerebroventricular ; NTS ; nucleus tractus solitarius ; OVLT ; organum vasculosum
• 刊名：Autonomic Neuroscience
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：202
• 期：Complete
• 页码：122-135
• 全文大小：2115 K
• 卷排序：202

文摘

Exendin-4 (i.c.v.) can induce emesis, reduce food intake and cause “nausea” in the ferret. Brainstem c-Fos increased only with emesis but mid-/fore-brain counts increased irrespective. Brainstem and midbrain c-Fos levels only correlate with the occurrence of emesis induced by exendin-4. Midbrain and forebrain c-Fos levels correlate irrespective of emesis induction by exendin-4. Exendin-4-induced BIN and amygdala c-Fos are sensitive to exendin (9–39), but anorexia is not.