Comparative investigation of the DNA inter-strand crosslinks induced by ACNU, BCNU, CCNU and FTMS using high-performance liquid chromatography-electrospray ionization tandem mass spectrometry
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- 作者：Lijiao Zhao ; zhaolijiao@bjut.edu.cn" class="auth_mail ; Lili Li ; Jie Xu ; Rugang Zhong
- 关键词：Chloroethylnitrosoureas ; DNA interstrand crosslinks ; Quantitative analysis ; HPLC&ndash ; ESI-MS/MS
- 刊名：International Journal of Mass Spectrometry
- 出版年：15 July 2014
- 年：2014
- 卷：368
- 期：Complete
- 页码：30-36
- 全文大小：1505 K
文摘
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DNA interstrand crosslinks induced by CENUs were determined using HPLC–MS/MS.
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The crosslinking activities of 4 types of CENU were compared.
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The crosslinking level induced by ACNU is much higher than the other 3 CENUs.
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A correlation was found between crosslinking level and anticancer efficiency.
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G–C crosslinking level is a potential biomarker for anticancer activity of CENUs.