The natural scorpion peptide, BmK NT1 activates voltage-gated sodium channels and produces neurotoxicity in primary cultured cerebellar granule cells
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- 作者：Xiaohan Zoua ; 1 ; Yuwei Hea ; 1 ; Jinping Qiaob ; Chunlei Zhanga ; ; Zhengyu Caoa ; zycao1999@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Buthus martensii Karsch ; BmK NT1 ; Cerebellar granule cells ; Neurotoxicity ; Voltage-gated sodium channels
- 刊名：Toxicon
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：109
- 期：Complete
- 页码：33-41
- 全文大小：1258 K
文摘
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BmK NT1, a natural mammalian toxin was purified from the scorpion venom.
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BmK NT1 produced a modest Na + influx and cell death in cultured neurons.
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BmK NT1-induced Na + influx and neuron death depended on the activation of VGSCs.